'FORMULATION amp; EVALUATION OF MOUTH DISSOLVING TABLET OF PEROXICAM'

摘要

The present invention relates to mouth dissolving tablet of Piroxicam. The formulation shows instantaneous pre gastric release of the drug in upper gastro intestinal tract which results in enhanced bioavailability of drug bypassing the first pass metabolism. The formulation is prepared by direct compression technique using superdisintegrants such as cross carmellose sodium and sodium starch glycolate with other excipients such as micro crystalline cellulose and D-mannitol as diluents, aspartame as sweeting agent, talc and magnesium stearate as glidant and lubricant respectively, colloidal silicon dioxide as disintegrant as well as glidant. The mouth dissolving tablet formulation of micronized Piroxicam can be used as novel drug dosage form as pediatrics and geriatrics with improved patients compliance and enhanced bioavailabity.