METHODS AND COMPOSITIONS FOR INHIBITION OF THE TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE

摘要

COMPOUNDS OF FORMULAS I-XLIII ARE IDENTIFIED AS DIRECT INHIBITORS OF P97 ATPASE OR OF THE DEGRADATION OF A P97-DEPENDENT UBIQUITIN-PROTEASOME SYSTEM (UPS) SUBSTRATE. METHODS AND COMPOSITIONS ARE DISCLOSED FOR INHIBITING P97 ATPASE AND THE DEGRADATION OF A P97-DEPENDENT UPS SUBSTRATE, AND FOR IDENTIFYING INHIBITORS THEREOF.