TECHNIQUE FOR CLEAVING OUT PART OF POLY(A) CHAIN AND/OR 3 TERMINAL SEQUENCE OF MRNA TO INHIBIT TRANSLATION REACTION

摘要

Provided is an artificial gene expression inhibition method which can be designed more readily compared with conventional methods (an RNAi method a ribozyme method an antisense method) and in which the effect thereof can be confirmed readily. Provided are: a method for inhibiting the translation reaction of a target gene which comprises cleaving out a part of a poly(A) chain and/or a 3 terminal sequence of target mRNA; a kit for inhibiting a translation reaction which comprises a reagent capable of cleaving out a part of a poly(A) chain and/or a 3 terminal sequence of target mRNA; a cell into which a reagent capable of cleaving out a part of a poly(A) chain and/or a 3 terminal sequence of target mRNA is introduced so as to inhibit the translation reaction of a target gene; and a non human living organism into which a reagent capable of cleaving out a part of a poly(A) chain and/or a 3 terminal sequence of target mRNA is introduced so as to inhibit the translation reaction of a target gene.