The present invention relates to the use of radiofrequency oxygen plasma treatment for surface modification of muga {Antheraea assama) silk fibroin (AASF) followed by antibiotic drug loading and subsequent development as antibiotic-loaded suture biomaterial. This invention provides an efficient, dry and environmentally-friendly method of modifying surface properties of AASF for developing it as antibiotic-loaded suture biomaterial. The method i.e. radiofrequency oxygen plasma treatment described in this invention involves low consumption of energy, chemical and time as compared to wet chemical/radiation treatment and more importantly can effectively modify the surface properties of polymeric materials without influencing their bulk properties which is difficult to achieve through wet chemical/radiation treatment processes. This invention provides an effective solution on eliminating post surgical bacterial infection of wound and significant improvement in rapid wound healing activity though development of antibiotic-loaded AASF suture by radiofrequency oxygen plasma treatment.
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