A FUSION PROTEIN, COMPOSITION COMPRISING IT, NUCLEIC ACID MOLECULE ENCODING SUCH FUSION PROTEIN AND VECTOR COMPRISING SAID NUCLEIC ACID

摘要

Multimeric fusion proteins of an Ig-like domain of Flt-1 are rendered functional by inclusion or a linker moiety. Vectors encoding the fusion proteins and host cells expressing the fusion proteins can be used therapeutically to block neovascu-larization in individuals with pathological conditions related to neovascularization. Such conditions include age-related macular degeneration, cancer, psoriasis, proliferative diabetic retinopathy, asthma, uveitis, osteoarthritis, and rheumatoid arthritis. The same means of multimerization used for an Ig-like domain of Flt-1, i.e.,a linker and a multimerization domain, can be used for other polypeptides, including extracellular receptors, antibody variable regions, cytokines, chemokines, and growth factors.