(2R,S)-2-butyryloxy-2-((R)R,S)- isobutoxyethoxyphosfinyleacetic acid and a process for its preparation

摘要

the invention concerns a new acid (2r, s) - 2 - butyryloksy - 2 - [((p) r, s) - izobutoksyetoksyfosfinylo] acetic acid of formula 1, which is intended for use as chiralny reagent chemical shift.the subject of the invention is also a process for the production of acid (2r, s) - 2 - butyryloksy - 2 - [((p) r, s) - izobutoksyetoksyfosfmylo] acetic acid of formula 1, having the glyoxylic acid is phosphorylated racemicznym fosforynem isobutyl ketone ethyl, whereby the reaction is in t emperaturze peaceful in the presence of trietyloaminy as catalyst for 2 hours.and then the mixture is dissolved in chloroform and carried out acetylowanie raw product butrylu chloride, and the resulting product is purified by column chromatography gravity.