首页> 外国专利> PROCESS FOR PREPARING BIOACTIVE COMPLEXES OF HEDERA HELIX HERBA AND MEDICINE PRODUCT TO BE USED IN ANTI-TUMOUR THERAPY

PROCESS FOR PREPARING BIOACTIVE COMPLEXES OF HEDERA HELIX HERBA AND MEDICINE PRODUCT TO BE USED IN ANTI-TUMOUR THERAPY

机译:制备用于抗肿瘤治疗的赫德拉草药和药物产品的生物活性复合物的方法

摘要

The invention relates to a phytotherapeutic product, a process for preparing the same and a medicine containing the same, used in the anti-tumor therapy. According to the invention, the phytotherapeutic product contains at least 90% of total triterpene monodesmoside saponins, aglycon hederagenin, of which 70...80% alpha-hederin, usable for preparing some bioactive intermediates. According to the invention, the process consists in the liquid/liquid extraction of a triterpene glycosides complex from Hedera Helix plant, in which the alpha-hederin is first separated by a liquid/liquid extraction with ethyl acetate, followed by the separation of bisdesmosidic glycoside compounds Hederacoside C, of which there result two purified preparations, a liquid bioactive complex and an aqueous CuNa-chlorophyl extract. According to the invention, the medicine product comprises 1...2% phytotherapeutic product conditioned with pharmaceutically acceptable ingredients, suitable to the administration type.
机译:本发明涉及用于抗肿瘤治疗的植物治疗产品,其制备方法和包含其的药物。根据本发明,该植物治疗产品含有至少90%的总三萜单糖苷皂苷皂苷配体皂苷配基,其中70 ... 80%的α-接枝素可用于制备一些生物活性中间体。根据本发明,该方法包括从Hedera Helix植物中液/液提取三萜糖苷复合物,其中首先通过用乙酸乙酯进行液/液分离来分离α-hederin,然后分离双糖苷化合物Hederacoside C,得到两种纯化的制剂,一种液态生物活性复合物和一种CuNa-叶绿素水溶液。根据本发明,药物产品包含1 ... 2%的植物治疗产品,其以适合于给药类型的药学上可接受的成分调节。

著录项

  • 公开/公告号RO125279B1

    专利类型

  • 公开/公告日2013-12-30

    原文格式PDF

  • 申请/专利权人 BIOTEHNOS S.A.;

    申请/专利号RO20090000863

  • 申请日2009-10-26

  • 分类号A61K9/16;A61K36/25;A61P31/00;

  • 国家 RO

  • 入库时间 2022-08-21 15:56:23

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