METHOD FOR IMMUNE DIAGNOSTICS OF THE STAGE OF HEPATIC DYSFUNCTION AND DEGREE OF ACUTE HEPATIC INSUFFICIENCY SEVERITY IN PATIENTS WITH NONNEOPLASTIC OBSTRUCTIVE JAUNDICE

摘要

A method for immune diagnostics of the stage of hepatic dysfunction and the degree of severity of acute hepatic insufficiency in patients with nonneoplastic obstructive jaundice includes the determination of the level of mediated with T-lymphocytes apoptosis (CD95) in patient’s blood serum at hospitalization, before surgical intervention and at post-operative period. The CD95 values of 7.3-7.5±0.05 % correspond to the level of total bilirubin up to 50 µmol/l, latent stage of acute hepatic insufficiency, stage of compensation of hepatic dysfunction. The CD95 values of 7.6-8.2±0.06 % correspond to the level of total bilirubin 51-100 µmol/l, light degree of acute hepatic insufficiency, stage of sub-compensation of hepatic dysfunction. The CD95 values of 8.2-8.5±0.05 % correspond to the level of total bilirubin 101-200 µmol/l, medium degree of acute hepatic insufficiency, stage of decompensation of hepatic dysfunction. The CD95 values 8.6±0.06 % correspond to the level of total bilirubin over 201 µmol/l, severe degree of acute hepatic insufficiency, terminal stage of hepatic dysfunction.