METHOD FOR PREDICTING NDIVIDUAL TREATMENT OF BREAST CANCER PATIENTS

摘要

A method for predicting the individual treatment of breast cancer patients comprises clinical-genealogical analysis, histopathological and immunohystological examination of tumor. The mutations 185delAG and 5382insC of BRCAI gene, mutations of p53 and glutathione-S-transferase genes GSTP1 and GSTT1 are assayed in the blood. The low expression of estrogen and progesterone in tumor (20 %) and the presence of BRCAI, p53, GSTP1 and GSTP2 mutations suggest the aggressive clinical course. The presence of mutated (VV) and heterozygous (iV) variants of GSTP1 polymorphism as well as the analogous variants (DD) and (iD) of GSTT1 gene is predictive of the increased sensitivity to the drugs used for polychemotherapy.