首页> 外国专利> HYDROCHLORIDE SALT OF ((1S,2S,4R)-4{4-(1S)-2,3-DIHYDRO-1H-INDEN-1-YLAMINO}-7H-PYROLO2,3-DPYRIMIDIN-7-YL}-2-HYDROXYCYCLOPENTYL)METHYL SULFAMATE

HYDROCHLORIDE SALT OF ((1S,2S,4R)-4{4-(1S)-2,3-DIHYDRO-1H-INDEN-1-YLAMINO}-7H-PYROLO2,3-DPYRIMIDIN-7-YL}-2-HYDROXYCYCLOPENTYL)METHYL SULFAMATE

机译:((1S,2S,4R)-4 {4-[(1S)-2,3-DIHYDRO-1H-INDEN-1-YLAMINO} -7H-PYROLO [2,3-D] PYRIMIDIN-7-的盐酸盐YL} -2-羟基环戊基)磺酸甲酯

摘要

Disclosed is a compound of formula ( I ): crystalline forms thereof, and solvates thereof; pharmaceutical compositions comprising a pharmaceutically effective amount of the compound of formula ( I ), or a crystalline form thereof, or a solvate thereof, and a pharmaceutically acceptable carrier or diluent; and the use of a compound of formula ( I ), or a crystalline form thereof, or a solvate thereof, for treating a patient suffering from, or subject to, a pathological condition capable of being ameliorated by inhibiting an E1 activating enzyme, particularly NAE, including, e.g., cancer.
机译:公开了式(I)的化合物:其结晶形式及其溶剂化物;药物组合物,其包含药学有效量的式(I)的化合物或其结晶形式或其溶剂化物,以及药学上可接受的载体或稀释剂;式(I)的化合物或其结晶形式或其溶剂化物在治疗或遭受能够通过抑制E1活化酶,特别是NAE而得以改善的病理状态的患者中的用途包括例如癌症。

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