PHOSPHORILATION IN THR-248 AND / OR THR-250 WASTE FROM THE E2F4 TRANSCRIPTION FACTOR AS A THERAPEUTIC TARGET IN PATHOLOGICAL PROCESSES COURTING BY SOMATIC POLYPLOIDY.

摘要

The object of the invention is based on inhibiting specific phosphorylation on Thr248 and/or Thr250 residues of human transcription factor E2F4 to inhibit somatic endoreduplication processes in postmitotic cells which may be associated with various pathological conditions. The invention covers all currently known methods for the specific inhibition of protein phosphorylation (including the expression of mutant forms of E2F4 without Thr residues phosphorylated by p38MAPK) or methods developed in the future that may be applied to Thr-248 and/or Thr-250 residues of human transcription factor E2F4.