Method of preparation of a crystalline form not susceptible to hydration

摘要

A method for preparing Polymorph A of 3-bromo-1- (3-chloro-2-pyridinyl) -N- [4-cyano-2-methyl-6 - [(methylamino) carbonyl] phenyl] -1H-pyrazole-5 -carboxamide; characterized by an X-ray diffraction pattern that has at least the reflection positions 2θ which comprises heating at a temperature between 40 ° C and the boiling point of the solvent a mixture comprising a solvent selected from the group consisting of water, n-heptane, 1 -chlorobutane, toluene, 1-butanol and 1-pentanol, and Polymorph B of 3-bromo-1- (3-chloro-2-pyridinyl) -N- [4-cyano-2-methyl-6 - [(methylamino) carbonyl ] phenyl] -1H-pyrazol-5-carboxamide; characterized by an X-ray diffraction pattern that has at least 2θ reflection positions