Procedure to determine the part of the mid-region of amino-terminal proANP in patients who present with heart disease or who are suspected to develop or have heart disease

摘要

In vitro procedure for medical diagnosis, prognosis and therapeutic follow-up for patients who present with heart disease or who are suspected to be developing or who have heart disease comprising the following stages: * provide a sample of a patient with heart disease or suspected of developing or presenting with heart disease, * determining the area of the mid-region of amino-terminal proANP, which comprises amino acid 50 to amino acid 90, or partial peptides thereof in said sample with a sandwich-type immunoassay that it uses two antibodies that specifically bind to different partial sequences of said zone of the mid-amino-terminal proANP region, * attribute the level of determined amino-terminal proANP or the level of the partial peptides thereof to a clinical picture in which Attribution to a clinical picture is carried out with the help of a limit value independent of BMI from 190 to 260 pmol / l.