Compounds represented by having sphingosine-1-phosphate receptor agonist and / or antagonist biological activity represented by the general formula: ** Formula ** wherein: R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen, straight or branched chain alkyl having 1 to 12 carbons, alkenyl having 2 to 6 carbons and 1 or 2 double bonds, alkynyl having 2 to 6 carbons and 1 or 2 triple bonds, carbocyclic hydrocarbon groups having 3 to 20 carbon atoms, heterocyclic groups having up to 20 carbon atoms and at least one of oxygen, nitrogen and / or ring sulfur, halo, C1 to C12 haloalkyl, hydroxyl, C1 to C12 alkoxy, C3 to C20 arylalkyloxy, alkyl C1 to C12 carbonyl, formyl, oxycarbonyl, carboxy, C1 to C12 alkyl carboxylate, C1 to C12 alkyl amide, aminocarbonyl, amino, cyano, diazo, nitro, thio, sulfoxyl and sulfonyl groups; X is NH; X1 is selected from the group consisting of NR5, O, and S; R5 is hydrogen, an alkyl group of 1 to 10 carbons, a cycloalkyl group of 5 to 10 carbons, phenyl or alkylphenyl where the alkyl group has 1-7 carbon atoms; Y is a phenyl group or a pyridyl group, each of which can be attached to A at any position; Z is O; n is 0 or an integer from 1 to 5; o is 0 or an integer from 1 to 3; p is 0 or an integer from 1 to 3; q is 1; r is 0 or 1; A is CH2; A1 and A2 are independently selected from the group consisting of (CH2) v where v is 0 or an integer from 1 to 12, branched chain alkyl having 3 to 12 carbons, cycloalkyl having 3 to 12 carbons, alkenyl which it has 2 to 10 carbons and 1-3 double bonds and alkynyl that has 2 to 10 carbons and 1 to 3 triple bonds; B is selected from the group consisting of hydrogen, OR6, COOR7, NR8R9, CONR8R9, COR10, CH = NOR11, CH = NNR12R13
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