The invention provides compounds represented by the formula I, each of which compounds may have sphingosine-1 -phosphate receptor agonist and or antagonist biological activity: and wherein the variables Y, RSUP4/SUP, n, A, X, Z, RSUP1/SUP, o, RSUP3/SUP, RSUP2/SUP and p are as defined in the specification. These compounds are useful for treating a disease or condition selected from the group consisting of glaucoma, dry eye, angiogenesis, cardiovascular conditions and diseases, and wound healing.
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