Use of cannabidiol in the treatment of chemotherapy-induced nausea and vomiting

摘要

Use of cannabidiol in the treatment of chemotherapy-induced nausea and vomiting The present invention relates to the use of cannabidiol in the treatment of chemotherapy-induced nausea. It is known that the cannabidiol compounds of the general formula I ** Formula ** where R 'represents CH3, COOH or CH2OH; and R "represents a. linear or branched alkyl of 5 to 12 carbon atoms; b. a group -O-R '' ', where R' '' is linear or branched alkyl of 5 to 9 carbon atoms, or a linear or branched alkyl substituted on the terminal carbon atom with a phenyl group; c. a group - (CH2) nO-alkyl, where n is an integer from 1 to 7 and the alkyl group contains from 1 to 5 carbon atoms , are anti-inflammatory agents and have analgesic, anti-anxiety, anticonvulsant, neuroprotective, antipsychotic and anti-cancer activity There are many known compounds that are present in marijuana that have anti-nausea and anti-vomiting activity, however many of them are psychoactive, which is not desired for For this purpose, it has now been found that the cannabidiol compounds of the general formula are not psychoactive but are very useful in the treatment of nausea and anti-vomiting activity.Therefore, the present invention consists in the use of compounds of can Nabidiol of general formula I in the treatment of nausea and vomiting activity. The compounds are used in particular in the treatment of chemotherapy-induced nausea. The cannabidiol compound of formula II and / or its DMH homologue of formula III can be used as such. In addition, it can be used as part of a pharmaceutical preparation that is selected from a tablet, a capsule, a granule, a suspension in a solution, etc. Said pharmaceutical preparation may comprise, in addition to the active ingredient, an excipient selected from a vehicle, a disintegrating agent, a lubricant, a stabilizer, a flavoring agent, a diluent, another effective pharmaceutical compound, etc. The diluent may be an aqueous cosolvent solution comprising a pharmaceutically acceptable cosolvent, a micellar solution prepared with natural or synthetic surfactants and ionic or non-ionic, or a combination of said cosolvent and said micellar solutions, etc. The vehicle can basically consist of an ethanol solution, a surfactant or water, or basically an emulsion comprising triglycerides, lecithin, glycerol, an emulsifier, an antioxidant, water, etc. The present invention will be described hereinafter in detail. The Figures illustrate the following reactions.