2,5,6,7-tetrahydro- compounds 1,4 oxazepine-3-ylamine 2,3,6,7-tetrahydro- or 1,4 oxazepine-5-ylamine

摘要

Compounds of formula wherein A is O and B is -CR8R9-; or B is O and A is - CR8R9; R1 is selected from the group consisting of hydrogen, C1-7-cycloalkyl-C3-7 and; R2 is selected from the group consisting of hydrogen, C1-7-cycloalkyl-C3-7 and; R3 is selected from the group consisting of hydrogen, halogen, C1-7-alkyl and C3-7 cycloalkyl-; R4 is selected from the group consisting of hydrogen, halogen, C1-7-alkyl and C3-7 cycloalkyl-; R5 is alkyl-C1-7 cycloalkyl-C3-7 or; or R3 and R5 together with the carbon atom to which they are attached form a cyclopropyl ring; R6a, R6b, R6c and R6d, independently of each other are selected from the group consisting of hydrogen, C1-7 -alkyl, halogen and haloalkyl-C1-7; R7 is - (CO) -R10 or R11, wherein R10 is selected from the group consisting of aryl, said aryl being unsubstituted or substituted by one, two or three groups selected from the group consisting of alkyl- C1-7, halogen, C1-7-alkyl-halogen, C 1-7 -alkoxy, halogen-C 1-7 -alkoxy, cyano, hydroxy alkyl-C1-7, oxo and phenyl, heteroaryl, said heteroaryl or being substituted substituted by one, two or three groups selected from the group consisting of alkyl-C1-7, halogen, C1-7-alkyl-halogen, C 1-7 -alkoxy, halogen-C 1-7 -alkoxy, cyano, hydroxy- alkyl-C1-7, oxo and phenyl-C1-7 alkyl-C1-7 alkyl-halogen, C3-7 cycloalkyl-, said cycloalkyl being unsubstituted or substituted by one, two, three or four groups selected from the group consisting of alkyl-C1-7, halogen or haloalkyl-C1-7, and C1-7 alkoxy-C1-7-alkyl-; R11 is selected from the group consisting of alkyl-C1-7 cycloalkyl-C3-7 and, said substituted or unsubstituted cycloalkyl substituted by one, two, three or four groups selected from the group consisting of alkyl-C1 -7, halogen and halogen- C1-7-, R8 and R9 are independently selected from each other from hydrogen, alkyl and cycloalkyl-C1-7-C3- 7; or pharmaceutically acceptable salts thereof.