Derivatives of di (hetero) arilciclohexano, their preparation, their use and pharmaceutical compositions comprising

摘要

A compound of formula I, wherein Ar 1 is phenyl or pyridinyl, all optionally substituted with 1, 2 or 3 identical or different from the series consisting of halogen, (C1-C5), cycloalkyl (C3-C6) -CvH2v-, Ar3, (C1-C5) -O-, -O-alkyl (C1-C3) -O, (C3-C6) -S (O) f- and (C1-C5) -S (O) k-, wherein all alkyl groups and cycloalkyl groups in Ar 1 are optionally substituted with one or more fluorine substituents; Ar2 is phenyl, naphthyl or heteroaryl, all optionally substituted with 1, 2 or 3 identical or different substituents from the series consisting of halogen, cyano, (C1-C5), cycloalkyl (C3-C6) -CvH2v-, Ar3, (C1-C5) -O-, -O-alkyl (C1-C3) -O, (C3-C6) -S (O) f- and (C1-C5) -S (O) k-, wherein all alkyl groups and cycloalkyl groups Ar2 are optionally substituted with one or more fluorine substituents; Ar3 is phenyl or pyridinyl, all optionally substituted with 1, 2 or 3 identical or different substituents from the series consisting of halogen, (C1-C5) alkyl, (C1-C5) -O-, -O-alkyl (C1 -C3) -O and (C1-C5) -S (O) m-, wherein all alkyl groups are optionally substituted with Ar3 one or more fluoro substituents; Ar4 is phenyl, pyridinyl or pyrimidinyl, all optionally substituted with 1, 2 or 3 identical or different substituents from the series consisting of halogen, (C1-C5) alkyl, (C1-C5) alkyl and -O- (C1- C5) -S (O) n-, where all alkyl groups Ar4 are optionally substituted with one or more fluorine substituents; R1 is R4-O- or R5R6N-; R2 is hydrogen, (C1-C8), Ar4, R17-O-alkyl (C1-C8) -, or Het-C u H 2u (C3-C8) -CuH2u-, wherein all alkyl groups and cycloalkyl groups in R2 are optionally substituted with one or more fluorine substituents; R4, R5 and R6, which are all independent of one another and can be identical or different, are hydrogen, (C1-C5) or cycloalkyl (C3-C6) -CpH2p-, where all alkyl groups and cycloalkyl groups R4, R5 and R6 are optionally substituted with one or more fluorine substituents; R17 is hydrogen, (C1-C5) or cycloalkyl (C3-C6) -CqH2q-, wherein all alkyl groups and cycloalkyl groups in R17 are optionally substituted with one or more fluorine substituents; Het is a residue of a saturated ring of 4-membered to 7-membered monocyclic containing one oxygen atom as ring heteroatom, which is bonded by a carbon atom which ring is optionally substituted with 1, 2 or 3 identical or different substituents the series consisting of phenyl and (C1-C5), wherein the phenyl groups Het are optionally substituted by 1 or 2 identical or different substituents from the series consisting of halogen, (C1-C5) alkyl and ( C1-C5) -O-, and wherein Het and all alkyl in Het are optionally substituted with one or more fluorine substituents; heteroaryl is a residue of an aromatic 5-membered ring or 6 member monocyclic or 9-membered or 10-membered bicyclic series consisting of thienyl, pyrazolyl, imidazolyl, [1,2,4] triazolyl, thiazolyl, pyridinyl, indolyl, benzodioxolyl, benzimidazolyl, 4,5,6,7-tetrahidrobenzoimidazolilo, imidazo [4,5-b] pyridinyl, quinolinyl and isoquinolinyl;