biopolymer aqueous solution controlled temperature and pH dependent self-gelling

摘要

A self-gelling liquid composition allows the formation of biopolymer gels controlled temperature and pH dependent at a temperature between 30 and 80 ° C, comprising: a) an acid medium based on water, b) 0.1 to 10 % by weight of a soluble biopolymer gelling acids share the selected pH of collagen and chitosan biopolymer carrying cationic amino groups, c) 0.1 to 10% by weight of a water soluble molecule capable of capturing protons in aqueous solution thereby giving rise to an increase in pH, selected from the group consisting of: - sodium, magnesium or iron N- [carbamoylmethyl] -2-aminoethane sulfonate (ACES), N, N-bis [2- hydroxyethyl] -2-aminoethane sulfonate (BES), 3- [N, N-bis (2-hydroxyethyl) amino] -2-hydroxypropane sulfonate (DIPSO), N- [2-hydroxyethyl] piperazine-N'-3- propane sulfonate (EPPS), N- [2- hydroxyethyl] piperazine-N'-4-butane sulfonate (HepBs), N- [2-hydroxyethyl] piperazine-N'-2-ethanesulfonate ( HEPES), N- [2-hydroxyethyl] piperazine-N'-2-hydroxypropane sulfonate (HEPSO), 2- [N-morpholino] ethanesulfonate (MES), 4- [N-morpholino] butane sulfonate (MOBS), 3- [N-morpholino] propane sulfonate (MOPS), 3- [N-morpholino] -2-hydroxypropane-sulfonate (MOPSO), piperazine-N ', N'-bis [2-ethanesulfonate] (PIPES), piperazine-N , N'-bis [2-hydroxypropanesulfonate] (POPSO), 3- [Ntris (hydroxymethyl) methylamino] -2-hydroxypropanesulfonate (TAPSO), or Ntris [hydroxymethyl] methyl-2-aminoethane sulfonate (TES) or mixtures thereof; - N, N-bis [hydroxyethyl] glycine (BICINE), bis [2-hydroxyethyl] iminotris- [hydroxymethyl] methane (BIS-TRIS), glycylglycine (Gly-Gly), triethanolamine (TEA), N-tris [ hydroxymethyl] methylglycine (TRICINE), tris [hydroxymethyl] aminomethane (TRIZMA), or mixtures thereof; - an amino acid residue selected from the group consisting of histidine, arginine, lysine, asparagine, and glutamine or a mixture thereof, amino acid residue which is optionally modified with an acetyl, t-butyl, benzyl, benzoyl, ethyl, formyl, or methyl; - an amino acid sequence which includes alanine, histidine, arginine, lysine, aspartic acid, glutamine, glycine, hydroxyproline, isoleucine, leucine, norleucine, phenylalanine, proline, serine, threonine, tyrosine, or valine, wherein said liquid composition has a pH end ranging from 5.8 to 7.4.