KDR and VEGF / KDR binding peptides and their use in diagnosis

摘要

A compound comprising an optical conjugate directly or through a linker or a spacer with at least one polypeptide having the ability to bind to KDR or VEGF / KDR complex comprising an amino acid sequence selected from: AGDSWCSTEYTYCEMIGTGGGK (SEQ ID N .º: 4), AGPKWCEEDWYYCMITGTGGGK (SEQ ID NO: 5), AGVWECAKTFPFCHWFGTGGGK (SEQ ID NO: 6), AGWVECWWKSGQCYEFGTGGGK (SEQ ID NO: 7), AGWIQCNSITGHCTSKGTG ID: 8 AGWIECYHPDGICYHFGTGGGK (SEQ ID NO: 9), AGSDWCRVDWYYCWLMGTGGGK (SEQ ID NO: 10), AGANWCEEDWYYCFITGTGGGK (SEQ ID NO: 11), AGANWCEEDWYYCWITGTGTGW (SEC ID: TWGGWG) No: 13), AGSNWCEEDWYYCYITGTGGGK (SEQ ID NO: 14), AGPDWCAADWYYCYITGTGGGK (SEQ ID NO: 15), AGPEWCEVDWYYCWLLGTGGGK (SEQ ID NO: 16), AGPTWCEDDWYYCWLFGTGGGK (SEQ ID NO: 17), AGSKWCEQDWYYCWLLGTGGGK (SEQ ID NO: 18), AGRNWCEEDWYYCFITGTGGGK (SEQ ID NO: 19), AGVNWCEEDWYYCWITGTGGGK (SEQ ID NO: 20), AGANWCEEDWYYCYITGTGGGK (S EC ID No.: 21), AGQAWVECYAETGYCWPRSWGTGGGK (SEQ ID NO: 22), AGQAWIECYAEDGYCWPRSWGTGGGK (SEQ ID NO: 23), AGVGWVECYQSTGFCYHSRDGTGGGK (SEQ IDW No .: 24G 25), AGDSWVECDAQTGFCYSFLYGTGGGK (SEQ ID NO: 26), AGERWVECRAETGFCYTWVSGTGGGK (SEQ ID NO: 27), AGGGWVECRAETGHCQEYRLGTGGGK (SEQ ID NO: 28), AGVAWVECYQTTGKGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG ID No.: 30), GDSRVCWEDSWGGEVCFRYDPGGGK (SEQ ID NO: 31), GDDSYCMMNEKGWWNCYLYDPGGGK (SEQ ID NO: 32), GDPAQCWESNYQGIFFCDNPDPGGGK (SEQ ID NO: 33),