ENHANCEMENT OF ANTIBODY-CYTOKINE FUSION PROTEIN MEDIATED IMMUNE RESPONSES BY COMBINED TREATMENT WITH IMMUNOCYTOKINE UPTAKE ENHANCING AGENTS

摘要

Disclosed are compositions for treating tumors and the use of suchcompositions. Disclosed compositions enhance the uptake of immunocytokinesintotumors, and are based on a combination of an immunocytokine with animmunocytokineuptake enhancing agent. The immune uptake enhancing agent is taxol, docetaxel,10-deacetylBaccatin III, cyclophosphamid or carboplatin, and can be administered to amammal prior to the immunokine. Disclosed compositions are particularly usefulforreducing tumor size and metastasis in a mammal.