PEPTIDE-BASED IMMUNIZATION THERAPY FOR TREATMENT OF ATHEROSCLEROSIS AND DEVELOPMENT OF PEPTIDE-BASED ASSAY FOR DETERMINATION OF IMMUNE RESPONSES AGAINST OXIDIZED LOW DENSITY LIPOPROTEIN

摘要

The present invention relates to fragments of apolipoprotein B, in particulardefined peptides thereof, for immunization or therapeutic treatment ofmammals, including humans, against ischemic cardiovascular diseases, as wellas diagnosing the presence or absence of antibodies related to increased ordecreased risk of developing ischemic cardiovascular diseases, using one ormore of said peptides in an ELISA (Enzyme Linked Immuno Sorbent Assay).