S-DIMETHYLARSINO-THIOSUCCINIC ACID S-DIMETHYLARSINO-2-THIOBENZOIC ACID S-(DIMETHYLARSINO) GLUTATHIONE AS TREATMENTS FOR CANCER

摘要

Arsenic trioxide, an inorganic compound, is commercially available anti-canceragent but it carries significant toxicity. Organic arsenicals, on the otherhand, are much less toxic, to the extent that the methylation of inorganicarsenic in vivo into organic arsenicals has been considered a detoxificationreaction. New organic arsenic derivatives have been synthesized, including S-dimethylarsino-glutatione, S-dimethylarisno-thiosuccinic acid and S-dimethylarsino-thiobenzoic acid, and established its potent in vitro cytotoxicactivity against numerous human tumor cell lines, both of solid andhematological origin, as well as against malignant blood cells from patientswith leukemia. Results form a basis for the development of S-dimethylarsino-glutathione, S-dimethylarsino-thiosuccinic acid, S-dimethylarsino-thiobenzonicacid, and other organic arsenicals as an anti-cancer therapy, combining highefficacy with very low, if any, toxicity.