PRODUCTION OF DICARBOXYLIC ACIDS BY IMPROVED MUTANT STRAINS OF YARROWIA LIPOLYTICA

摘要

The invention relates to a process for the production of dicarboxylic acids (DCA) with long hydrocarbon chains, also called diacids, in which a mutant strain of Yarrowia lipolytica obtained by directed mutagenesis is cultured and more particularly disrupted at least for the POX2 genes. , POX3, POX4 and POX5 coding for Pacyl-CoA oxidase, in a medium consisting essentially of an energetic substrate which comprises at least one carbon source and a nitrogen source and said strain is subjected to a bioconversion substrate chosen from the n-alkanes of at least 10 carbon atoms, fatty acids of at least 10 carbon atoms, their alkyl esters and natural oils.