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SIRNA-HYDROPHILIC POLYMER CONJUGATES FOR INTRACELLULAR DELIVERY OF SIRNA AND METHOD THEREOF
SIRNA-HYDROPHILIC POLYMER CONJUGATES FOR INTRACELLULAR DELIVERY OF SIRNA AND METHOD THEREOF
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机译:用于siRNA细胞内递送的siRNA-亲水性聚合物缀合物及其方法
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摘要
Disclosed are hybrid conjugates formed by covalently bonding siRNA (smallinterfering RNA) molecules to hydrophilic polymers for improving stability ofthe siRNA molecules effective for gene therapy in vivo, and polyelectrolytecomplex micelles formed by ionic interactions between the conjugates andmultifunctional cationic compounds. The siRNA-hydrophilic polymer conjugatesand polyelectrolyte complex micelles derived therefrom can be advantageouslyused for improving stability of the siRNA molecules in vivo. Consequently, thedelivery of siRNA molecules for therapeutic applications into cells can befacilitated, and the siRNA is still active even though a small dose of thesiRNA is used.
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