CHIRAL LIGANDS USED IN TRANSITION METAL CATALYSTS FOR ASYMMETRIC ADDITION REACTIONS ESPECIALLY HYDROGENATION

摘要

The invention provides a compound of the formula l having at least two chiralcentresin the form of mixtures of diastereomers or pure diastereomers, whereinformula l is:secondary phosphine-Q-P*(=O)HR1 in which secondary phosphine is a secondaryphosphine group with hydrocarbon radicals or heterohydrocarbon radicals assubstituents. The compound of formula l may be used in preparing a metalcomplexwith a transition metal, and the metal complex may be used as a catalyst inpreparinga chiral organic compound by asymmetric addition of hydrogen to a carbon orcarbon-heteroatom double bond in a prochiral organic compound.