PH-SENSITIVE CARRIER AND PREPARATION METHOD THEREOF, AND PH SENSITIVE DRUG AND PH SENSITIVE DRUG COMPOSITION EACH CONTAINING THE CARRIER, AND CULTURE METHOD USING THE SAME

摘要

Provided are: a pH-sensitive carrier which can be used as a carrier for a physiologically active substance and can respond to a weakly acidic environment to exhibit an effect of promoting a membrane-disrupting function; a method for producing the pH-sensitive carrier; a pH-sensitive medicine and a pH-sensitive pharmaceutical composition, each of which contains the carrier; and a culture method using the pH-sensitive medicine or the pH-sensitive pharmaceutical composition. A pH-sensitive carrier which can exhibit an effect of promoting a membrane-disrupting function, said pH-sensitive carrier comprising: at least one pH-sensitive compound selected from the group consisting of deoxycholic acid, cholic acid, ursodeoxycholic acid, chenodeoxycholic acid, hyodeoxycholic acid, a higher bile acid, glycodeoxycholic acid, glycyrrhizic acid, glycyrrhetinic acid and salts thereof; and at least one amphipathic substance selected from the group consisting of a phosphatidylcholine having 10 to 12 carbon atoms, a polyoxyethylene sorbitan mono-fatty acid ester having 12 to 18 carbon atoms, a sorbitan fatty acid ester having 16 to 18 carbon atoms, glycerol monooleate, glycerol dilaurate, glycerol distearate, glycerol dioleate, polyoxyethylene castor oil and a-tocopherol.