INHIBITION OF ANGIOGENESIS, TUMORIGENESIS AND CATHEPSIN ACTIVITY USING INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN

摘要

Insulin-like growth factor binding proteins (IGFBPs) and variants thereof, including IGFBP-1, IGFBP-2, IGFBP-3, IGFBP-4, IGFBP-5, IGFBP-6 and the C-terminal fragments thereof, inhibit angiogenesis, tumorigenesis and cathepsin activity, particularly cathepsin B activity.