METHODS OF TREATING CANCERS WITH HER3 AND PIK3CA ANTISENSE OLIGONUCLEOTIDES

摘要

One aspect of the invention provides methods for treating hyperproliferative disorders such as cancers in a mammal using a combination of antisense oligomers directed against HER3 and PIK3CA. Cancers treatable according to the invention include those resistant to treatment with one or more protein tyrosine kinase inhibitors. Also provided are pharmaceutical compositions including the antisense oligomers.