Triazole derivatives which are Smo antagonists

摘要

The present invention provides a method for the treatment or prevention of conditionswhich can be ameliorated by Smo antagonism, which method comprises administrationto a patient in need thereof of an effective amount of a compound of formula I ora composition comprising a compound of formula I: or a pharmaceutically acceptablesalt or solvate thereof; wherein: 2 of X, Y and Z represent nitrogen atoms, andthe other represents an oxygen atom; R