Methods of treating a patient with a pharmacological agent that can induce liver toxicity selected from the group consisting of cholesteryl transfer protein inhibitors, anticoagulation agents, and anti-arrhythmic agents, are provided. In particular, the methods comprise: measuring the level of apolipoprotein in a bodily fluid from the patient; and comparing the measured level of apolipoprotein in the sample with a reference value in a patient population; wherein the patient is administered a pharmacological agent if the measurement is less than or equal to the reference value.
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