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Non-peptide agonists and antagonists of adrenomedullin and gastrin releasing peptide
Non-peptide agonists and antagonists of adrenomedullin and gastrin releasing peptide
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机译:肾上腺髓质素和胃泌素释放肽的非肽激动剂和拮抗剂
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#$%^&*AU2010214693C120140123.pdf#####ABSTRACT This invention relates, e.g., to methods for inhibiting or stimulating an activity of an adrenomedullin (AM) or gastrin releasing peptide (GRP) peptide hormone, comprising 5 contacting the peptide with a small molecule, non-peptide, modulatory agent of the invention. Complexes of these modulatory agents with other components, such as the peptides or blocking antibodies specific for the peptides, are also described, as are pharmaceutical compositions comprising the modulatory agents, and methods for using the modulatory agents to diagnose or treat patients.1/9 SUBSTRATE COLORED PRODUCT PEROXIDASE MONOCLONAL ANTIBODY A A A LIBRARY COMPOUNDS PLATE BOTTOM FIG. 1A r 1 2 3 4 5 6 7 8 9 10 11 12 A --- Tr- A B C FIG. 1B
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