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Double-stranded oligonucleotide compounds for treating hearing and balance disorders
Double-stranded oligonucleotide compounds for treating hearing and balance disorders
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机译:用于治疗听力和平衡障碍的双链寡核苷酸化合物
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摘要
The present application relates to double stranded nucleic acid compounds, compositions comprising same and methods of use thereof for the treatment of hearing loss in a subject in need thereof. The compounds are preferably chemically synthesized and modified dsRNA molecules which inhibit expression of a gene expressed selected from the group consisting of HES1, HES5, HEY1, HEY2, ID1, ID2, ID3, CDKN1B, and NOTCHl.
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