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Direct Delivery of Antisense Oligonucleotides to the Middle and Inner Ear Improves Hearing and Balance in Usher Mice

机译：直接递送反义寡核苷酸与中耳和内耳改善了母龄小鼠的听力和平衡

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Jennifer J. Lentz; Bifeng Pan; Abhilash Ponnath; Christopher M. Tran; Carl Nist-Lund; Alice Galvin; Hannah Goldberg; Katelyn N. Robillard; Francine M. Jodelka; Hamilton E. Farris; Jun Huang; Tianwen Chen; Hong Zhu; Wu Zhou; Frank Rigo; Michelle L. Hastings; Gwenaëlle S.G. Géléoc;
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1. Improved directional hearing of children with congenital unilateral conductive hearing loss implanted with an active bone-conduction implant or an active middle ear implant [J] . K. Vogt, H. Frenzel, S.A. Ausili, Hearing Research: An International Journal . 2018,第期

机译：改善了植入活性骨传导植入物或活性中耳植入物的先天性单侧导电性听力损失的定向听力
2. Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency 10-fold in mice [J] . Prakash TP, Graham MJ, Yu JH, Nucleic Acids Research . 2014,第13期

机译：使用Triantennarary N-乙酰基半乳糖胺对肝细胞的靶向反义寡核苷酸的递送改善了小鼠的效力10倍
3. Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency 10-fold in mice [J] . Alfred Chappell, Audrey Low, Brett P. Monia, Nucleic acids research . 2014,第13期

机译：使用三天线N-乙酰半乳糖胺将反义寡核苷酸靶向肝细胞的递送可将小鼠的效力提高10倍
4. Enhancing antisense oligonucleotide efficacy in vivo by improving both antisense design using RNAse H accessibility mapping and sustained hippocampal delivery using biodegradeabile microspheres [C] . A.Islam, K.S.J.thompson, S.Akhtar, International symposium on controlled release of bioactive materials;Consumer and diversified products conference . 2000

机译：通过改善使用RNAse H可及性作图的反义设计和使用可生物降解的微球体持续进行海马递送来增强体内反义寡核苷酸的功效
5. Antisense oligonucleotides directed to the HIV-1 Rev Response Element: Effects of nucleotide modification on oligo binding affinity, nuclease stability, and cellular uptake. [D] . Prater, Chrissy E. 2006

机译：针对HIV-1 Rev反应元件的反义寡核苷酸：核苷酸修饰对寡核苷酸结合亲和力，核酸酶稳定性和细胞摄取的影响。
6. NAR Breakthrough Article: Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency 10-fold in mice [O] . Thazha P. Prakash, Mark J. Graham, Jinghua Yu, 2014

机译：NAR突破性文章：使用三天线N-乙酰半乳糖胺将反义寡核苷酸定向递送至肝细胞可将小鼠的效力提高10倍
7. Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency 10-fold in mice [O] . Thazha P. Prakash, Mark J. Graham, Jinghua Yu, 2014

机译：使用Triantennarary N-乙酰基半乳糖胺对肝细胞的靶向反义寡核苷酸的递送改善了小鼠的效力10倍

Direct Delivery of Antisense Oligonucleotides to the Middle and Inner Ear Improves Hearing and Balance in Usher Mice

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