Partial MCH constructs and methods of use

摘要

Disclosed herein are isolated major histocompatibility complex (MHC) class II al domain polypeptides and methods of use. In some embodiments, the isolated polypeptide comprises or consists of an MHC class H al domain polypeptide (or portion thereof) and does not include an MHC class II α2, β1, or β2 domain. The disclosed MHC class H al domain polypeptides are of use in treating or inhibiting disorders in a subject, such as inflammatory and/or autoimmune disorders. Also disclosed are methods of evaluating efficacy of treatment or optimizing treatment of a subject with a polypeptide including an MHC class II al domain polypeptide (or portion thereof) or a polypeptide including an MHC class II al domain and β1 domain (such as a β1α1 RTL).