Use of bone marrow cells for long term culture of pancreatic islet cells.

摘要

#$%^&*AU2014218470A120140918.pdf#####ABSTRACT Bone marrow cells have been demonstrated to be useful in the maintenance of pancreatic ) islet f cell viability, structure, and/or function in culture for a sustained period. Bone marrow cells were also found to promote p cell growth while reducing inflammatory cytokine release and reduce apoptosis. Moreover, islet cells co-cultured with bone marrow cells were shown to retain insulin response function and to function in an islet cell transplant in a mouse model of diabetes to restore normal insulin secretion. Cord blood cells and isolated peripheral CD34+ blood cells were unable to support f islet cell growth or increase survival... ... ... .. .. ... .. .. ------- ---~~J:,~11 sm; no)2 ~t ith thowM j l ""Al., 'WN