A CONTROL POINT INTERPOLATION METHOD FOR THE QUANTIFICATION OF CEREBRAL HAEMODYNAMICS

摘要

The present invention provides a method which involves the deconvolution of the concentration time curve in tissue with an arterial input function (AIF), of the following equation: Formula (I) where C(t) is the measured concentration time curve (CTC), (⊗ represents convolution, the proportionality constant α is a measure of brain tissue density and difference in hematocrit between capillaries and large vessels, CBF is the cerebral blood flow and R(t) is the residue function, the residue function describing the fraction of a tracer remaining in the tissue vasculature at a time t after its arrival, wherein Control Points (CPs) are used to parameterise the residue function, the Control Points being interpolated to produce a smooth continuous residue function curve.