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USE OF THE CATHELICIDIN LL-37 PEPTIDE DERIVATIVES THEREOF FOR USE IN TREATING CHRONIC WOUNDS
USE OF THE CATHELICIDIN LL-37 PEPTIDE DERIVATIVES THEREOF FOR USE IN TREATING CHRONIC WOUNDS
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机译:鞘磷脂LL-37肽衍生物的使用,用于治疗慢性伤口
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摘要
Use of the antimicrobial cathelicidin peptide II-37, N-terminal fragments of LL-37 or extended sequences of LL-37 having 1-3 amino acids in the C-terminal end, for stimulating proliferation of epithelial and stromal cells and thereby healing of wounds, such as chronic ulcers. The cytotoxic effect of LL-37 may be reduced by including a bilayer-forming polar lipid, especially a digalactosyldiacylglycerol, in pharmaceutical compositions and growth media comprising LL-37.
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