AMINO-SUBSTITUTED RUTAECARPIN ANALOG AND SYNTHESIS METHOD AND USE THEREOF IN PREPARATION OF ANTI-OBESITY DRUG

摘要

The present invention relates to the fields of pharmaceutical chemistry and pharmaceutical therapeutics. Provided are an amino-substituted rutaecarpin analog and a synthesis method and use thereof in the preparation of an anti-obesity drug. An experiment confirms that the amino-substituted rutaecarpin analog of the present invention can dramatically reduce the lipopexia of 3T3-L1 fat cells, and can reduce the high levulose-induced lipopexia of FAO rat liver cells. A cellular level experiment indicates that the compound can reduce lipopexia, relieve obesity and alleviate fatty liver. The amino-substituted rutaecarpin analog has a chemical formula (I), wherein R₀=-NH(CH₂)_nR₂, n=1, 2, 3, 4 or 5, and R₂=-N(CH₃)₂, -N(CH₂CH₃)₂, cyclopentylamino or cyclohexylamino; or R₀= morpholinyl, piperazinyl or methylpiperazinyl.