Obesity predisposition evaluation method and kit, and anti-obesity drug and screening method thereof, non-human animal, adipose tissue, adipocyte, transgenic mouse preparation method, antigen, antibody

摘要

PROBLEM TO BE SOLVED: To provide a method and kit for evaluating whether or not predisposition to obesity is present, an anti-obesity drug having an action to prevent or treat obesity or a condition or disease caused by obesity, a screening method therefor, and a gene relating thereto To provide a deficient non-human animal, its adipose tissue or adipocyte. A method for evaluating whether obesity or a predisposition to cause a condition or disease caused by obesity, comprising using a sample containing a human gene of a subject, and a copy number polymorphism in intron 1 of SLC25A24 gene (CNV), or a step of detecting a genetic polymorphism in a linkage disequilibrium relationship therewith is provided. When CNV in intron 1 of the SLC25A24 gene is 0, it may be evaluated as having a predisposition for causing obesity or a condition or disease caused by obesity. [Selection] Figure 1