PROCESS FOR PROCUDING (2R,3S)-3-(4-METHOXYPHENYL)GLYDIDIC ACID ETHYL ESTER BY ENANTIOSELECTIVE HYDROLYSIS OF RACEMIC 3(4-METHOXYPHENYL)GLYCIDIC ACID METHYL ESTER EMPLOYING LIPASE DERIVED FROM SERRATIA MARCESCENS AND/OR CANDIDA CYLINDRACEA

摘要

The present invention relates to a process for producing an optically active (2S,3S)-3- hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one (Cis-lactam). More particularly, this invention relates to a process for making (2R,3S)-3-(4- methoxyphenyl)glycidic acid methyl ester employing enzymes, which is simple, industrially applicable and economically viable.