METHOD AND DEVICE FOR SPECIFICALLY CAPTURING CIRCULATING TUMOR CELL BY UTILIZING SURFACE OF FRACTAL STRUCTURE AND APPLICATION THEREOF

摘要

The present invention provides a method and a device for specifically capturing a circulating tumor cell by utilizing a surface of a fractal structure, and an application thereof. According to the present invention, a surface of a substrate is formed as a surface with a fractal structure; before being put into a cell culture plate, a specific antibody on a circulating tumor cell surface is fixed on the surface with the fractal structure; before being put into a cell culture incubator, a sample containing the circulating tumor cell to be captured is dropwise added to the surface of the specific antibody on the circulating tumor cell surface. Due to the synergetic effect between the specific antibody on the circulating tumor cell surface and the fractal structure, the circulating tumor cell in the sample is specifically captured. The capture method based on the surface with the fractal structure according to the present invention can be used to capture cells associated with cancer.