PHARMACEUTICAL COMPOSITION COMBINING VARIOUS VENOTONIC AND VASOPROTECTIVE AGENTS FOR THE TREATMENT OF CHRONIC VENOUS INSUFFICIENCY

摘要

The invention relates to a pharmaceutical composition comprising the synergic combination of three agents with venotonic and vasoprotective activity, known as a purified, micronized flavonoid fraction of diosmin and hesperidin and calcium dobesilate, as well as pharmaceutically acceptable excipients, which are formulated in a single dosage unit to be orally administered. The composition, which is used to control and treat chronic venous insufficiency, provides improved therapeutic effect and faster pharmacological action in less time, with smaller concentrations of the active principles and a reduction in the risk of severe complications and/or side effects.