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CHALCONE LINKED PYRROLO2,1-C1, 4BENZODIAZEPINE HYBRIDS AS POTENTIAL ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF
CHALCONE LINKED PYRROLO2,1-C1, 4BENZODIAZEPINE HYBRIDS AS POTENTIAL ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF
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机译：查尔酮联吡咯并[2,1-C [[1，4]苯并二氮杂INE杂物作为潜在的抗癌剂及其制备方法
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摘要
The present invention relates to chalcone linked pyrrolo[2,1-c][1,4]benzodiazepine hybrids and a process for the preparation there of. More particularly it relates to 7-Methoxy-8-{n[4-1-(2 or 4-substituted phenyl)-3-(4-hydroxy-3-methoxyphenyl)-2-propen-1-one]alkyl}-oxy}-(11aS)-1,2,3,11a-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one and 7-Methoxy-8-{n-[-3-(4-hydroxy-3-methoxyphenyl)-1-(2,4-alkyl-3-quinolyl)-2-propen-1-one]alkyl}-oxy-(11aS)-1,2,3,11a-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one with aliphatic chain length variations useful as anticancer (antitumor) agent. The general structural formula of these chalcone linked pyrrolo[2,1-c][1,4]benzodiazepines hybrids is given below. wherein R1=OH, methyl, ethyl or phenyl; R2=H, OH or F; R=H or methyl; x=c or N; n=1-4.
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机译：本发明涉及查尔酮连接的吡咯并[2，1-c] [1，4]苯并二氮杂杂化物及其制备方法。更具体地说，它涉及7-甲氧基-8- {n [4-1-（2或4-取代的苯基）-3-（4-羟基-3-甲氧基苯基）-2-丙烯-1-酮]烷基}-氧基}-（11aS）-1,2,3,11a-5H-吡咯并[2,1-c] [1,4]苯并二氮杂-5--1和7-甲氧基-8- {n-[-3-（ 4-羟基-3-甲氧基苯基）-1-（2,4-烷基-3-喹啉基）-2-丙烯-1-一]烷基}-氧基-（11aS）-1,2,3,11a-5H-具有脂肪族链长度变化的吡咯并[2,1-c] [1,4]苯并二氮杂-5-酮可用作抗癌剂。这些查尔酮连接的吡咯并[2,1-c] [1,4]苯并二氮杂杂化物的一般结构式如下。其中R1 ＝ OH，甲基，乙基或苯基; R 2 ＝ H，OH或F; R = H或甲基; x = c或N; n ＝ 1-4。
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