NANOSOMAL PREPARATION OF THE COMPLEX FORMED BY QUERCETIN (OR ANOTHER FLAVONOL, FLAVONE OR A DERIVATIVE THEREOF) AND 2-HYDROXYPROPYL-Β-CYCLODEXTRIN FOR INTRAVENOUS USE IN CEREBRAL PATHOLOGICAL CONDITIONS

摘要

The invention involves the preparation of cholesterol lecithin nanosomes, without propylene glycol, from the complex formed by quercetin (or another flavonol or flavone or a derivative thereof) and 2-hydroxypropyl-β-cyclodextrin, by means of a process that allows the safe, effective intravenous use thereof in the treatment of cerebral pathological conditions in adults and newborns. The preparation is safe, stabilizes the altered haemodynamic parameters in severe neonatal hypoxia in newborn pigs and is effective in protecting cerebral function in experimental Parkinson's disease models and in newborn pigs subject to hypoxia.