BIOCOMPATIBLE BONE REPLACEMENT MATERIAL AND METHOD FOR PRODUCING SAME

摘要

The invention relates to medicine, and more particularly to the production of biocompatible materials which can be used as bone replacement agents for filling defects in bone and cartilage tissues in traumatology, orthopedics and neurosurgery in the case of congenital and acquired diseases, and further relates to a drug delivery system. The biocompatible bone replacement material has through pores with a size of 0.7-100 μm and has a total porosity of 50-85%. The material is produced on the basis of a curing reaction mixture of biological hydroxyapatite and magnesium phosphate powders with particle sizes no greater than 40 μm, said mixture containing 2-amino-5-guanidinovaleric acid (arginine), and a tempering fluid (liquid phase) containing a solution of chitosan in succinic acid and a solution of sodium alginate. The curing agent calcium chloride is added to the material prior to use. The invention makes it possible to produce a bone replacement material which is fully biocompatible with bone tissue and exhibits biodegradability, and creates conditions that render bone tissue transplants and reoperation unnecessary.