NOVEL PROCESS FOR THE PREPARATION OF (1S,3AR,6AS)-2-(2S)-2-({(2S)-2-CYCLOHEXYL-2-(PYRAZIN-2-YLCARBONYL)AMINOACETYL}AMINO)-3,3-DIMETHYLBUTANOYL-N-(3S)-1-(CYCLOPROPYLAMINO)-1,2-DIOXOHEXAN-3-YL-3,3A,4,5,6,6A-HEXAHYDRO-1H-CYCLOPENTAC PYRROLE-1-CARBOXAMIDE AND ITS INTERMEDIATES

摘要

The present invention relates to novel process for the preparation of (1S,3aR,6aS)-2- [(2S)-2-({(2S)-2-cyclohexyl-2-[(pyrazin-2-ylcarbonyl)amino]acetyl}amino)-3,3-dimethylbutanoyl]-N-[(3S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl]-3,3a,4,5,6,6a-hexahydro-1H- cyclopenta[c] pyrrole- 1-carboxamide compound represented by the following structural formula- 1 and intermediates thereof. The present invention also provides crystalline polymorphs of intermediates of compound of formula- 1.