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HYDROXY-SUBSTITUTED GOLD(III) PORPHYRIN COMPLEXES AS HISTONE DEACETYLASE INHIBITORS
HYDROXY-SUBSTITUTED GOLD(III) PORPHYRIN COMPLEXES AS HISTONE DEACETYLASE INHIBITORS
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机译:羟基取代的金(III)卟啉配合物作为组氨酸去乙酰化抑制剂
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摘要
A method for treatment of cancer by inhibiting the activity of histone deacetylase, comprising administering to a human in need of such treatment a composition containing a therapeutically effective amount of a gold(III) complex having the structural formula of or a pharmaceutically acceptable salt thereof, wherein: -R is selected from the group consisting of -OH, -CH2OH, C2H4OH, -C3H6OH or -C4H8OH; and X is independently a pharmaceutically acceptable counter-ion.
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机译:一种通过抑制组蛋白脱乙酰基酶活性来治疗癌症的方法,该方法包括向需要这种治疗的人施用一种组合物,该组合物包含治疗有效量的具有以下结构式的金(III)配合物或其药学上可接受的盐,其中:-R选自-OH,-CH 2 OH,C 2 H 4 OH,-C 3 H 6 OH或-C 4 H 8 OH; X独立地是药学上可接受的抗衡离子。
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