ABA-TYPE TRIBLOCK COPOLYMER BASED ON MOLECULAR GLUE, SYNTHESIS THEREFOR, AND USE THEREOF

摘要

Disclosed are an ABA-type triblock copolymer based on a molecular glue, synthesis therefor, and use thereof. The structural formula of the copolymer is selected from the Formula (I). The copolymer of the present invention can be used to prepare a self-assembled medicine-carrying micelle. The present invention is based on the hydrophilicity of polyethylene glycol and chitosan of a low molecular weight, and on the hydrophobicity of polylactic acid, polycaprolactone, lauric acid, and stearate. Single chains of molecular glue having hydrogen bond sequence-selectivity are separately introduced into known macro-molecular polymers, such that under certain conditions, two complimentary single chains can form a molecular glue. A series of amphiphilic triblock copolymers can thereby effectively synthesized. Additionally, the molecular glue introduced contains a disulfide bond, and the copolymer is therefore sensitive to oxidoreduction. The raw material agents for the synthesis of the present invention can be easily obtained, the conditions are temperate, and the synthesis process contains only conventional chemical reactions and is suitable for large-scale production.