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PHOSPHORIC ACID ESTER COMPOUND OF HYDROXY ACID SUBSTITUTED PHENYL ESTER, SYNTHESIS METHOD AND MEDICAL USE THEREOF
PHOSPHORIC ACID ESTER COMPOUND OF HYDROXY ACID SUBSTITUTED PHENYL ESTER, SYNTHESIS METHOD AND MEDICAL USE THEREOF
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机译:羟基取代苯甲酸酯的磷酸酯化合物,合成方法及其医学用途
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摘要
Phosphate ester compound of hydroxy acid substituted phenyl ester, preparation method and medical use thereof are provided. The title compound is shown in formula (I), in which Y = C 1-4 straight carbon chain, M 1 and/or M 2 = H, alkali metal ion, protonated amine or protonated amino acid. The compound has good water solubility and high stability in its aqueous solution, and it can release 2, 6-diisopropylphenol rapidly under the action of enzymes in vivo, which has the effects of sedation, hypnosis and/or anesthesia. By protecting hydroxyl of 2, 6-diisopropylphenol in compound of formula (I), the first-pass metabolic activity of 2, 6-diisopropylphenol is reduced, so that the synthetic compound can be used for sedation, hypnosis and/or anesthesia.
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机译:提供了羟基取代苯基酯的磷酸酯化合物,其制备方法和医学用途。标题化合物如式(I)所示,其中Y = C 1-4直碳链,M 1和/或M 2 = H,碱金属离子,质子化胺或质子化氨基酸。该化合物在水中具有良好的水溶性和高稳定性,在体内酶的作用下可以迅速释放出2,6-二异丙基苯酚,具有镇静,催眠和/或麻醉作用。通过保护式(I)的化合物中的2,6-二异丙基苯酚的羟基,降低了2,6-二异丙基苯酚的首过代谢活性,使得合成的化合物可用于镇静,催眠和/或麻醉。
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